Efficacy

• Glucanol ™ Increases Microbial Killing. In clinical studies, Glucanol’s™ highly purified and biologically active 1-3,1-6 beta glucan significantly increased phagocytic capacity, the ability of the innate immune cells to eat and destroy foreign intruders. After 10 days of treatment, Glucanol™ had increased the percentage of immune cells able to phagocytose one particle from 63.8% to 83.2% (P< .05). The number of highly phagocytic cells increased from 37.3% to more than 50% (P< .05).

• Glucanol™ Increases Immune Cell Activity. A placebo-controlled, double-blinded clinical study conducted with 62 subjects to assess the impact of the ingredients in Glucanol™ on immune biomarkers for subjects exposed to rhinovirus (common cold) was conducted. Generally, the immune system responds to viral infections with an increase in Natural Killer (NK) cells and cytotoxic T cells as primary defense mechanisms. Participants receiving Glucanol’s™ ingredient had more NK cells and cytotoxic T Cells (12.5%) as a percent of all lymphocytes than participants in the control group (9.8%).

• Glucanol™ Enhances Immune Cell Migration to Site of Challenge. Glucanol’s™ active form enhances the ability of certain human immune cells to migrate to the site of a bacterial infection. Neutrophils, the most abundant type of innate immune cell in the body, are attracted to the site of an infection by blood proteins called chemo-attractants and are among the first cells of the body to respond to a challenge due to infection or injury. Priming neutrophils with Glucanol’s™ pharmaceutical grade 1-3,1-6 beta glucan increases their ability to sense complement fragments emanating from the site of an infection. As a result, a more rapid immune response to infection results in faster microbial clearance and healing.

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Safety

Studies demonstrate Glucanol™ safely enhances and supports healthy immune system function.

• Animal tox studies with doses ranging from 0 to 1,000 times recommended daily dose.

• Human studies with doses up to 60 times recommended daily dose.

• No increase in tested cytokines or other adverse effects.
  
  
• Glucanol™ increased ability of human immune cells to kill foreign challenges.
  
  
  

  Bibliography The bibliography below is separated by disease state or 1-3, 1-6 beta glucan effect. You will see the same citation under a number of headings because the research produced results that were important for each. This peer reviewed research touches important topics such as: Adjuvants Aging Antibiotics Antimicrobial Activity Antioxidants Anthrax Arthritis Athereoschlerosis Bacterial Infection Bone Marrow Injury Burn – Oxidative Organ Damage Cancer Cancer – Carcinoma of the Breast Cancer – Ovarian Cancer – Sarcoma Cancer – Sarcoma and Melanoma Cancer – Radiotherapy Candida albicans Chemotherapy Cholesterol Control Chronic Fatigue Syndrome Coronary Artery Disease Diabetes/Glucose Control Escherichia coli Free Radical Scavinger Fungal Disease and Pathogens Hemopoietic Recovery Hepatitis – Viral Immune Response Potentiation Impared Immunity Infections Irradiation Injury Leukemia Lipid Metabolism Liver Damage Macrophage Activation Melanoma Methotrexate Toxicity Mycotoxins Oxidative Damage Parasites Platelet Recovery Pneumonia Radiation Damage Protection Rheumatoid Arthritis Safety – FDA Classification Spinal Cord Injury Stem Cell Tranplantation Trauma Tumors Viral Diseases White Blood Cell Recovery Wound Healing